R Charles Coombes Selected Research

Hormones (Hormone)

5/2024	Correction: Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study.
1/2024	Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study.
1/2021	Detection of Multiple Breast Cancer ESR1 Mutations on an ISFET Based Lab-on-Chip Platform.
1/2020	CDK7 inhibitors as anticancer drugs.
1/2018	ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.
3/2014	Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation.
8/2011	High-dose chemotherapy with autologous stem-cell support as adjuvant therapy in breast cancer: overview of 15 randomized trials.
6/2009	A 2009 update on the treatment of patients with hormone receptor-positive breast cancer.
3/2006	Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor.
8/2005	A pooled analysis of bone marrow micrometastasis in breast cancer.

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R Charles Coombes Research Topics

Disease

118	Breast Neoplasms (Breast Cancer) 05/2024 - 09/2003
89	Neoplasms (Cancer) 04/2024 - 01/2002
14	Neoplasm Metastasis (Metastasis) 11/2023 - 08/2005
6	Circulating Neoplastic Cells 01/2023 - 02/2011
3	Triple Negative Breast Neoplasms 08/2015 - 03/2007
3	Carcinogenesis 01/2014 - 10/2003
2	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2021 - 09/2008
2	Lymphatic Metastasis 01/2019 - 08/2005
2	Carcinoma (Carcinomatosis) 06/2017 - 01/2014
2	Prostatic Neoplasms (Prostate Cancer) 03/2014 - 12/2011
2	Residual Neoplasm 02/2012 - 03/2005
2	Necrosis 06/2008 - 11/2006
2	Bone Resorption 02/2008 - 02/2007
2	Neoplasm Micrometastasis 08/2005 - 03/2005
1	Pancreatic Neoplasms (Pancreatic Cancer) 12/2021
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2018

Drug/Important Bio-Agent (IBA)

28	Estrogen ReceptorsIBA 10/2022 - 12/2003
18	Proteins (Proteins, Gene)FDA Link 12/2016 - 01/2002
17	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2002
16	Tamoxifen FDA LinkGeneric 05/2019 - 09/2003
14	DNA (Deoxyribonucleic Acid)IBA 11/2023 - 09/2006
11	Aromatase InhibitorsIBA 09/2017 - 09/2003
11	Estrogen Receptor alphaIBA 07/2015 - 12/2004
10	Hormones (Hormone)IBA 05/2024 - 08/2005
10	Messenger RNA (mRNA)IBA 04/2021 - 10/2003
8	Cell-Free Nucleic AcidsIBA 01/2023 - 02/2012
8	exemestane (Aromasin)FDA Link 05/2019 - 03/2004
7	Estrogens (Estrogen)FDA Link 10/2022 - 12/2003
6	Transcription Factors (Transcription Factor)IBA 01/2018 - 01/2006
5	Steryl-Sulfatase (Steroid Sulfatase)IBA 11/2017 - 03/2006
5	irosustatIBA 11/2017 - 03/2006
5	Docetaxel (Taxotere)FDA Link 04/2012 - 02/2008
4	AntigensIBA 04/2024 - 01/2006
4	Peptides (Polypeptides)IBA 11/2017 - 01/2006
4	Paclitaxel (Taxol)FDA LinkGeneric 06/2017 - 12/2003
4	Epirubicin (Ellence)FDA LinkGeneric 07/2013 - 06/2005
4	Histone Deacetylase InhibitorsIBA 10/2006 - 01/2002
4	theasinensin AIBA 10/2006 - 12/2004
3	ZincIBA 12/2021 - 01/2015
3	LigandsIBA 12/2021 - 12/2003
3	MicroRNAs (MicroRNA)IBA 10/2021 - 05/2013
3	Phenobarbital (Luminal)FDA Link 04/2021 - 09/2015
3	Antineoplastic Agents (Antineoplastics)IBA 01/2019 - 01/2002
3	Small Interfering RNA (siRNA)IBA 06/2017 - 07/2009
3	Phosphotransferases (Kinase)IBA 04/2012 - 01/2006
3	Choline (Choline Chloride)IBA 12/2011 - 09/2009
3	ErbB Receptors (EGF Receptor)IBA 09/2011 - 06/2005
3	Trastuzumab (Herceptin)FDA Link 04/2011 - 07/2010
3	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 01/2010 - 09/2006
3	Gefitinib (Iressa)FDA Link 03/2009 - 06/2005
3	Anastrozole (Arimidex)FDA LinkGeneric 02/2008 - 09/2003
3	trichostatin A (A 300)IBA 10/2006 - 12/2004
3	Cyclin D1IBA 02/2006 - 12/2004
2	Circulating Tumor DNAIBA 04/2024 - 01/2021
2	IsotopesIBA 12/2021 - 01/2021
2	Progesterone Receptors (Progesterone Receptor)IBA 09/2021 - 09/2009
2	Cadherins (E-Cadherin)IBA 04/2021 - 01/2019
2	Cytosine DeaminaseIBA 01/2021 - 11/2017
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 02/2017 - 07/2009
2	human ERBB2 proteinIBA 02/2017 - 08/2011
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2017 - 12/2010
2	ChromatinIBA 01/2016 - 10/2015
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 08/2015 - 05/2009
2	Monoclonal AntibodiesIBA 07/2015 - 11/2014
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 11/2014 - 10/2012
2	Voltage-Gated Sodium ChannelsIBA 03/2014 - 08/2005
2	Ion Channels (Ion Channel)IBA 03/2014 - 08/2005
2	SteroidsIBA 03/2014 - 03/2006
2	Indicators and Reagents (Reagents)IBA 01/2014 - 01/2007
2	Lapatinib (GW572016)FDA Link 01/2013 - 07/2009
2	EnzymesIBA 10/2012 - 03/2006
2	taxaneIBA 04/2012 - 08/2011
2	Forkhead Box Protein M1IBA 09/2011 - 01/2010
2	AnthracyclinesIBA 08/2011 - 02/2008
2	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2011 - 04/2004
2	Epidermal Growth Factor (EGF)IBA 07/2010 - 09/2009
2	Protein Isoforms (Isoforms)IBA 09/2008 - 10/2003
2	alovudineIBA 09/2007 - 11/2005
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 09/2007 - 06/2005
2	UbiquitinIBA 02/2006 - 02/2006
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2005 - 01/2002
1	A-Form DNA (A-DNA)IBA 11/2023
1	TFXIBA 01/2023
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2021
1	MetalloproteinsIBA 12/2021
1	SulfurIBA 12/2021
1	Hydroxyl RadicalIBA 12/2021
1	Tumor Biomarkers (Tumor Markers)IBA 11/2021
1	Celecoxib (Celebrex)FDA Link 09/2021
1	Alkaline PhosphataseIBA 12/2019
1	Silicon Dioxide (Silica)FDA LinkGeneric 07/2019
1	Zinc Oxide FDA Link 07/2019
1	Glutathione (Reduced Glutathione)IBA 07/2019
1	Aldo-Keto ReductasesIBA 01/2019

Therapy/Procedure

65	Therapeutics 05/2024 - 09/2003
14	Drug Therapy (Chemotherapy) 10/2021 - 09/2007
3	Adjuvant Chemotherapy 04/2024 - 11/2009
3	Aftercare (After-Treatment) 11/2009 - 03/2006
2	Immunotherapy 01/2014 - 01/2006
1	Precision Medicine 11/2023